Enclomiphene (12.5mg/ml)

Enclomiphene citrate is a non-steroidal selective estrogen receptor modulator (SERM) that acts as an antagonist at the estrogen receptors in the hypothalamus and pituitary gland. It is one of the two isomers of clomiphene citrate, better known under the brand name Clomid.

Structurally, it represents the isolated trans-isomer (E-configuration) of clomiphene citrate, separating it completely from its geometric twin, zuclomiphene (the cis-isomer). Whereas zuclomifene is more estrogenic, enclomifene is more antiestrogenic.

• Enclomiphene is the isomer that blocks estrogen receptors and stimulates testosterone production.
• Zuclomiphene is longer-acting, displays mild estrogenic activity, and may contribute to side effects.

Blocking estrogen receptors in these tissues prevents negative feedback inhibition of gonadotropin release, leading to increased production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This signals the testes to increase testosterone production.

Enclomifene demonstrates the ability to restore testosterone production without the introduction of exogenous androgens. This has made it a popular choice among bodybuilders and athletes for the purpose of post-cycle therapy after a cycle of selective androgen receptor modulators (SARMs) and anabolic androgenic steroids (AAS).

How does enclomiphene work?

While most SERMs (selective estrogen receptor modulators) block some estrogen receptors in the body, Enclo blocks all estrogen receptors throughout the body. It then stimulates the release of follicle-stimulating hormones by antagonizing the negative feedback on gonadotropin-releasing hormone (GnRH).

Mechanism of action

Enclomiphene is a selective estrogen receptor antagonist, antagonizing the estrogen receptors in the pituitary gland. It disrupts estrogen’s negative feedback on the HPG axis, ultimately increasing gonadotropin secretion. This improves testosterone production, as well as sperm production.

Research has shown that enclo raises both free and available testosterone levels, without increasing dihydrotestosterone.

• Blocks estrogen in hypothalamic and pituitary tissues
• Elevates LH and FSH production from the pituitary gland
• Increased GnRH secretion from the hypothalamus
• Stimulates endogenous testosterone production
• Preserves fertility by maintaining FSH levels

Key benefits

Raises Endogenous Testosterone

Enclomiphene stimulates LH and FSH, which signal the testes to make more testosterone. This mechanism helps restore hormonal balance without suppressing the body’s natural production.  It works differently from traditional testosterone replacement therapy, which replaces testosterone using an exogenous source.

Preserves Fertility

Because LH and FSH remain active, sperm production is maintained. A 2023 head-to-head study of enclomiphene vs. clomiphene showed a significant rise in total motile sperm count with the e-isomer.

Potential side effects

Reported side effects are generally mild and include headache, nausea, or digestive discomfort. Some men experience transient increases in estradiol.

Enclomiphene dosage

Dosages used in research

Information about the most optimal enclomiphene dose comes from both human trials and preclinical research. What follows is an overview of the dosages used in research studies.

• 12.5 mg to 25 mg administered in a single daily dose in clinical studies
• 25 mg daily used in male hypogonadism research
• 6.25 mg to 12.5 mg administered during a cycle of SARMs to prevent suppression of natural testosterone production

Dosages used in post-cycle therapy

The enclomiphene protocol for recovery after a cycle of SARMs or anabolic steroids is based on both clinical data and a vast amount of anecdotal evidence from user reports.

• 12.5 mg to 25 mg per day for a period of 4 weeks, immediately taken after finishing a cycle of suppressive agents

Legal status

Enclomiphene has not been approved by the FDA or EMA for human consumption or therapeutic use. While clomifene, better known as Clomid, is a prescription drug, the e-clomiphene isomer is not approved as a licensed medicine in the EU. It can therefore not be legally prescribed or sold as a supplement. You can only buy enclomiphene from HQSARMS for research purposes.

Why buy from HQSARMS

Some of the benefits of purchasing at HQSARMS:

• Consistent purity and concentration, tested in-house and verified by third-party lab testing
• Highly discreet packaging and shipping, which prevents any issues
• Guaranteed delivery for all orders, making sure that you will never end up empty handed

Product specifications