What is MK-777 (Acetamoren)?
MK-777, also known as Acetamoren, is a synthetic, orally active, non-peptide, small molecule investigated in laboratory research as a growth hormone secretagogue and ghrelin receptor agonist. It is designed as an analog of earlier growth hormone secretagogues (GHS) compounds, such as MK-677.
It is being studied for its ability to promote growth hormone (GH) and insulin-like growth factor-1 (IGF-1) signaling via activation of the ghrelin receptor (GHS-R1a) in preclinical settings.
Unlike peptide-based GH secretagogues such as Ipamorelin, MK-777 is orally bioavailable and designed for enhanced pharmacokinetics, providing more predictable blood levels and potentially greater therapeutic utility.
While structurally very closely related to MK-677, Acetamoren is considered a distinct compound with its own unique profile.
Key characteristics
- Analog of MK-677 (Ibutamoren)
- Activates the ghrelin receptor (GHS-R1a)
- Developed by independent research labs
- Designed for experimental and analytical purposes
- Non-hormonal compound
- Supplied for research use only
MK-777 potential benefits
Acetamoren is a very new compound, and unlike Ibutamoren, there are currently no peer-reviewed clinical or preclinical studies on this compound. Therefore, the potential benefits listed below are entirely based on theoretical models and anecdotal user reports.
Enhanced growth hormone release
MK-777 acts as a strong GHS-R1a agonist, stimulating pulsatile secretion of growth hormone (GH) and potentially increasing circulating levels of IGF-1. This mechanism can aid in recovery, cellular repair, and anabolic processes.
Improved selectivity
MK-777 is hypothesized to exhibit higher receptor affinity and an optimized design, demonstrating greater selectivity than Ibutamoren. This may lead to a reduced side-effect profile and more consistent outcomes.
Limited effect on appetite
Compared to Ibutamoren, MK-777 is said to have a minimal effect on appetite, which is considered a massive benefit for anyone not actively trying to gain weight (bulking).
MK-777 vs MK-677 (Ibutamoren)
| Feature | MK-677 (Ibutamoren) | MK-777 (Acetamoren) |
|---|---|---|
| Generation | First-generation GH secretagogue | Next-generation analog |
| Mechanism | Ghrelin receptor agonist | Selective ghrelin receptor analog |
| GH/IGF-1 Output | Strong and well-documented | Expected similar, under study |
| Appetite Response | Strong ghrelin-like hunger increase | Theoretically moderate appetite effect |
| Water Retention | Common side effect | Possibly reduced retention |
| Metabolic Stability | Slight insulin sensitivity impact | Designed for smoother glucose balance |
| Research Stage | Extensively studied | Early exploratory phase |
Legal status
Acetamoren has not been approved by the FDA or EMA for human consumption or therapeutic use. It can therefore not be legally prescribed or sold as a supplement.
While not explicitly named, MK-777 is banned by the WADA under section S2.2.4, which includes growth hormone secretagogues (GHS) and their mimetics.
HQSARMS Acetamoren (MK-777) is strictly intended for research purposes only.
Product specifications
| Application | Non-peptide ghrelin receptor agonist |
| Form | Liquid |
| Concentration | 20mg per ml |
| Composition | 88% PEG-400, 10% ethanol, 2% MK-777 |
| Storage | Room temperature, out of direct sunlight |
| Storage life | 2 years |
| CAS | 950841-87-9 |
| Molar Mass | 570.7 g/mol |
| Chemical Formula | C₁₄H₂₀N₂O₂ |
| Synonyms | MK 777, Acetamoren |
