Enclomiphene: Is it the ultimate PCT for SARMs?

What Is Enclomiphene?

Enclomiphene is a selective estrogen receptor modulator (SERM), placing it in the same class as Clomid (Clomiphene citrate), but with a cleaner profile and more targeted effects. In fact, Enclomiphene is the more active isomer of Clomid, responsible for the compound’s testosterone-boosting properties without the brain fog and mood swings that many users report from Clomid.

It was originally developed to treat secondary hypogonadism, which is a condition where the testes stop producing enough testosterone due to disrupted signaling from the brain. It works by blocking estrogen receptors in the hypothalamus. This tricks the brain into thinking estrogen is low, which in turn causes an increase in luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones stimulate testosterone production in the testes.

It also raises total serum testosterone levels in men. This makes an Enclomiphene PCT for bodybuilding a popular choice among athletes and bodybuilders.

What is Post-cycle therapy?

Post-cycle therapy, or simply PCT for short, is a protocol used by individuals after completing a cycle of compounds that suppress natural testosterone levels. This includes anabolic-androgenic steroids (AAS), but to a lesser extent also SARMs (Selective Androgen Receptor Modulators) such as RAD-140, LGD-4033, YK-11, and S-4.

The primary function of post-cycle therapy is to restore the body’s natural hormone balance, particularly testosterone production, as well as reduce possible side effects that suppressed testosterone levels may cause. The side effects of decreased testosterone levels may include:

• Low libido or erectile dysfunction
• Fatigue, brain fog, or poor sleep
• Mood swings, irritability, or depression
• Loss of muscle mass or strength
• Increased body fat, especially around the waist

What happens if PCT is skipped?

When the body’s natural testosterone production is suppressed after running a cycle of SARMs or steroids, PCT is what will speed up recovery. The results of skipping post-cycle therapy can include:

• Longer recovery time: Your HPG axis may take months to restart naturally
• Muscle loss: Without testosterone, catabolism increases
• Estrogen rebound: Bloating, mood issues, or even gynecomastia
• Permanent damage: In rare cases, prolonged suppression can lead to hypogonadism

Is Post-cycle therapy required with SARMs?

The use of a PCT after a cycle of androgenic anabolic steroids (AAS) has been a widespread practice among bodybuilders and athletes alike for many years. It is generally accepted that after a cycle of androgenic anabolic steroids, it is simply a must in speeding up recovery and preventing unwanted side effects such as gynecomastia.

This kind of consensus is less obvious when it comes to SARMs, because they do not suppress natural testosterone levels to the same degree as their steroid counterparts. The question of whether post-cycle therapy is essential after running a SARM cycle seems like an obvious one.

The answer to this question is not a clear-cut yes or no, but it depends on various factors. Because not all SARMs are equally suppressive, the need for post-cycle therapy depends on the specific SARM, the dosage, and the duration of use.

Let’s be clear: not all SARMs are equally suppressive, but most medium to high-dose cycles — especially those longer than 6 weeks or involving compounds like RAD-140, YK-11, or LGD-4033 — will suppress natural testosterone production to some degree.

Here’s what can happen if you don’t run a proper Post Cycle Therapy (PCT):

• Testosterone stays low, even weeks after your last dose.
• Estrogen may rebound, leading to water retention, fat gain, and low libido.
• You may lose a significant portion of your gains as catabolic hormones dominate.
• You risk developing long-term hormonal issues, especially with repeated cycles.

That’s why a solid PCT protocol is non-negotiable — and Enclo is one of the best tools for the job.

How does an Enclomiphene PCT work?

When SARMs suppress your testosterone, your hypothalamic-pituitary-gonadal (HPG) axis goes offline. This axis controls your body’s natural hormone production. Enclomiphene reactivates that system by blocking estrogen’s negative feedback loop and promoting LH/FSH secretion.

Here’s what this does for your body:

• Restores natural testosterone levels faster
• Minimizes estrogen rebound
• Helps preserve muscle mass and strength post-cycle
• Supports mood, libido, and energy levels

Enclomiphene vs Clomid

When comparing Clomid and enclomiphene, most studies indicate that enclomiphene provides similar testosterone-boosting benefits as Clomid, but with fewer side effects and a shorter duration in the body. The zuclomiphene component of Clomid can lead to mood swings, irritability, and prolonged estrogenic effects.

Many lifters have used Clomid for years, but side effects are widespread and include:

• Mood swings
• Blurred vision
• Brain fog
• Estrogenic side effects (due to its zuclomiphene isomer)

Enclomiphene, being pure enclomiphene citrate, doesn’t carry these downsides. Users often report a sharper mental state, better mood, and fewer issues with emotional instability during PCT.

Enclomiphene as a Test-Base During a SARMs Cycle

One of the biggest misconceptions about SARMs is that they don’t suppress testosterone “enough” to need a base. But suppression is dose-dependent, and SARMs like RAD-140, YK-11, or S-23 can suppress you hard — especially in longer cycles or aggressive stacks.

Running Enclo during the cycle is a strategy some experienced users adopt to prevent testosterone levels from crashing too low. In this use case, it acts as a testosterone support. Not by replacing testosterone like TRT would, but stimulating natural production to keep levels from tanking.

Benefits of Using Enclomiphene as a Base:

• Prevents the low-testosterone symptoms during a SARMs cycle: fatigue, low libido, mood swings
• Helps maintain more consistent strength and performance
• Supports libido and sexual function throughout the cycle
• May reduce or delay the need for a harsh PCT afterwards

It’s not a full substitute for exogenous testosterone, but for SARMs-only users who want to avoid injections or TRT, it’s an excellent middle ground.

Enclomiphene Dosage and Cycle Length

The use of Enclomiphene in post-cycle therapy in bodybuilding is relatively new when compared to compounds such as Nolvadex and Clomid. Its effect on serum testosterone levels has been determined in human trials.

In the following overview, you will find the results of this study, which studied the average increase in total serum testosterone after 14 days of enclomiphene citrate use, with various dosages.

We can use the results of this study, combined with anecdotal evidence and user reports, to setup a protocol.

Enclomiphene dosage for post-cycle therapy

• Extra-heavy dose period – Take 50mg of the medication for 14 days, every day.
• After heavy dose period – Take 25mg of the medication for 14 days, every day.
• Average dose – Take 12.5mg of the medication for 14 days, every day.

For a typical 8-week SARMs cycle, a 4-week Enclomiphene PCT is often sufficient. Here’s a simple protocol following a cycle of SARMs:

Week 1–2: 25mg daily

Week 3–4: 12.5–25mg daily (taper depending on how you feel)

If your cycle involved very suppressive compounds or was longer than 8 weeks, you may want to extend PCT to 5–6 weeks.

Enclomiphene dosage during cycle

Another way Enclomiphene is used in bodybuilding is as a “Test base” instead of PCT. In this case, it is used during the actual SARM cycle, rather than after it is finished. The purpose is to keep natural testosterone levels elevated, with the goal of:

• Increasing gains
• Preventing problems with libido
• Minimizing the need for recovery after finishing the cycle

When used as a “test base”, the recommended enclomiphene dosage is lower than what would be used in PCT. A possible protocol could look as follows:

Week 1–4: 6.25mg daily

Week 5–8: 12.5mg daily

Benefits of Enclomiphene citrate for Bodybuilding 

Enclomiphene presents an up-and-coming treatment option for men with hypogonadism or as a PCT option. It offers the most benefits of TRT (Testosterone replacement therapy) without the usual drawbacks.

Because of its short half-life of only 10 hours, Enclomiphene is effective within just a few days of initial use.

For post-cycle therapy within the context of bodybuilding, it provides several benefits, including:

• Increased testosterone production
• Improved mood and libido
• Increased muscle mass
  

Increased testosterone production

Enclomiphene is the only SERM that is being seriously studied as a treatment for hypogonadism. It is extremely effective at boosting Testosterone levels, and more and more anecdotal evidence is coming out proving that it is an excellent PCT option as well as an excellent test base for SARM cycles.

It is also extremely effective at increasing fertility and sperm count, and is capable of reversing testicular atrophy after a cycle.

Improved mood and libido

Given that all SERMs can increase Testosterone levels, you would expect all of them to increase sex drive and improve one’s mood. The reality is that most SERMs will either have a neutral or even negative on both mood and libido. Enclomiphene seems to be the only exception.

Increased muscle mass

While enclomiphene does not have anabolic properties, its effectiveness in raising testosterone levels may result in increased muscle mass. This is despite the fact that it lowers IGF-1 levels.

Side Effects of Enclomiphene citrate

Enclomiphene is generally well tolerated with minimal side effects occurring rarely, such as headache (in less than 4% of patients), nausea (less than 3%), and joint pain (less than 2%). The medication may also increase testicular size, unlike TRT, which is associated with testicular shrinkage.

Decreased IGF-1 levels

Based on research, we know that one of the side effects of enclomiphene is that it lowers IGF-1 levels. While this is seen as a possible benefit in the context of this particular research, IGF-1 has anabolic properties of its own. However, the drop in IGF-1 levels is not nearly so severe that it would negate the anabolic effects associated with the rise in testosterone levels.

Some users advocate the use of MK-677 in combination with enclo, because that raises IGF-1 levels. While this would certainly be effective in regards to this, it is important to mention that MK-677 does a lot more than just raise IGF-1.

Increased aggression

According to both anecdotal evidence and reports, Enclomiphene can cause something similar to what is commonly known as “Roid Rage”. Users report feeling more masculine, aggressive and impatient, which is not unexpected for a substance that raises testosterone levels.

Where to buy Enclomiphene citrate?

Enclomiphene Citrate is hard to obtain in legitimate form due to the prevalence of low-quality suppliers and fake products. 

If you are interested in buying Enclomiphene citrate, we encourage you to review the purity reports available for each product batch.  That way, you can rest assured knowing that each purchase you make is backed up by scientific evidence proving its quality. 

Our mission here at HQSARMS is to ensure that all of the Enclomiphene Citrate we sell is genuine and of the highest calibre, so you don’t have to worry about using a product that could damage your health or well-being.

Additionally, if you have any queries or concerns about your order, please do not hesitate to contact us; we will always try our best to help solve your issues promptly.

Final Thoughts

Whether you’re recovering after a SARMs cycle or trying to maintain optimal function during one, Enclomiphene offers a powerful yet cleaner solution. Compared to traditional options like Clomid or Nolvadex, it provides:

✅ Faster testosterone recovery
✅ Fewer side effects
✅ Sharper focus and mood
✅ Greater convenience and flexibility

Frequently asked questions

References

1. Nettles, K. W., et al. (2008).
   Selective Estrogen Receptor Modulators (SERMs) and their function.
2. Taylor, F., et al. (2015).
   Enclomiphene citrate stimulates endogenous testosterone production in men with secondary hypogonadism.